For example, Sadahira et al. stated that gossypol was able to trigger cell death by the inhibition of the phosphorylation of JAK2, STAT3, ERK1/2, and p38 kinases in multiple myeloma [43], and Mehner et al. showed that AT101 in combination with desmethoxycurcumin yielded anti-proliferative effects via the reduction of the phosphorylation of the ERK signal in human primary GBM cells [19]. This evidence concerns the gene JAK2 and plasma cell myeloma.