IL1B and infection: After entering the target cells, the virus is tracked by pattern recognition receptors such as Toll-like receptors 3, 7, 8, and 9 and viral-infection sensors RIG-I and MDA5; different Tool Like Receptor (TLRs) trigger the transcription of the NLR family pyrin domain containing 3 (NLRP3) gene, and contribute to the activation of the inflammasome complexes, inducing the production of key proinflammatory cytokines IL-1β and IL-18 as well as the caspase-1 activation [29].