TARDBP and amyotrophic lateral sclerosis: Since patients with ALS and dementia also often have transactive response DNA binding protein 43 kDa (TDP-43) positive inclusions, the clinical and neuropathological term frontotemporal lobar degeneration with motor neuron disease and TDP-43 positive inclusions (FTLD-MND-TDP) became widespread, although it is less common today.