Similarly, a study with a larger sample size of type 2 diabetic patients (n = 302) reported elevated levels of MMP-2 in patients with PAD and diabetes, compared to non-PAD diabetics, which was accompanied with an increase in elastin degradation products (ELM), suggesting the regulation of MMP-2 and ELM by hyperglycemia in patients with PAD [73]. This evidence concerns the gene MMP2 and Hyperglycemia.