CRP and complication: The circulating concentrations of some cytokines (C reactive protein (CRP) or Interleukin (IL)-6), coagulation factors (D-dimer or fibrinogen), proteases (Matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs)) or cardiac damage markers have been reported to be increased in PAD patients according to pathological stages and CV complications [10,11,12,13], while other oxidative stress markers, and angiogenesis-related molecules rendered inconclusive results [12].