BAK1 and breast carcinoma: In MCF7 breast cancer cells, the intrinsic apoptotic pathway induced Caspase-9 and the pro-apoptotic Bak and Bax protein levels were significantly increased at 72 h (p < 0.033, p < 0.033, and p < 0.001, respectively), in line with the significant reduction of the anti-apoptotic Mcl-1 protein (p < 0.033).