LRP2 and autoimmune disease: The first evidence for MN as a kidney-limited autoimmune disease was derived via the immunization of rats with kidney extracts (Heymann nephritis rats) in 1959 [9]; this animal model was instrumental in the subsequent identification of GP330 or megalin expressed on the podocyte surface as the antigen for membranous glomerulonephritis developed in Heymann nephritis rats [10].