Children with TS develop subependymal giant cell astrocytoma, a specific subtype of astrocytoma, while children with NF-1 show a predilection for optic gliomas, a subtype of PA [6,52], while in adulthood patients with NF-1 tend to develop high-grade gliomas [53,54]. The gene discussed is NF1; the disease is astrocytoma (excluding glioblastoma).