As systolic and diastolic BP (in a normal to slightly elevated range) were significantly related to CySS and similarly responded to CPAP at unchanged BMI, glycemic marker, plasma lipids, homocysteine, or circulating TNF, our data may be indicative of an early non-radical based vascular risk through high plasma CySS with OSA-related cHPX in addition to that through OBS. This evidence concerns the gene TNF and obstructive sleep apnea syndrome.