NFKB1 and chronic obstructive pulmonary disease: Such an adaptive antioxidative mechanism may help to maintain or increase GSH levels in several tissues in the presence of increased lipid oxidation, CRP, and NF-κB-activation with CIH (with clinically relevant mild O2-desaturation), at least in rats [28], and may be involved in the somewhat unexpectedly increased GSH-synthesis in PBMC of smokers or COPD patients [50,62,63].