CRP and hypertensive disorder: More relevant to the present study, it was shown in healthy non-smokers aged 20–70 years that CySS was significantly negatively correlated to endothelial function (i.e., endothelial-dependent, but not endothelium-independent, vasodilation) as an early endpoint of developing hypertension yielding strong prediction even after adjustment for the Framingham risk score and C-reactive protein [41].