VEGFA and neoplasm: Agents that inhibit VEGF signaling can: “normalize” tumor blood vessels; create a radiosensitive microenvironment [27,32,33]; enhance radiation damage to endothelial cells by promoting vessel regression and tumor cell death; suppress waves of reoxygenation, and hence reduce radiotherapy resistance [34]; promote ceramide-mediated apoptosis, to enhance the effect of radiotherapy [35]; and reduce the acute mobilization of circulating endothelial cells and endothelial progenitor cells [27,32,33].