For example, PARP activation has been demonstrated, or PARylation has been implicated, in collagen production/fibrosis in the kidneys of cholestatic rats [21], in the heart and lungs of mice with LPS-induced myocardial or pulmonary fibrosis [20,27], in the liver of carbon tetrachloride-treated mice [28], in bleomycin-induced pulmonary fibrosis [29] and in angiotensin II-induced aorta fibrosis [30]. This evidence concerns the gene AGT and pulmonary fibrosis.