CASP8 and non-small cell lung carcinoma: Edmond et al. showed that, following treatment of non-small cell lung cancer cells with cisplatin, nuclear-localized SRPK2 induced apoptosis through regulation of the splicing switch of caspase-8 pre-mRNA [22], while Jang et al. showed that nuclear import of SRPK2 led to cyclin D1 upregulation, cell cycle re-entry, and neuronal apoptosis [39].