Additionally, the authors showed an inverse correlation of Beclin-1 and LC3 expression with serum globulin levels, which may suggest that high levels of Beclin-1 and LC3 expression may result in higher autophagic activity; hence, there may be better survival in the Beclin-1 group and Highly expressed LC3, suggesting a possible cytoprotective effect of autophagy in multiple myeloma [196]. This evidence concerns the gene BECN1 and plasma cell myeloma.