ITIH4 and cancer: Figure 2B shows the relative expression of each protein compared to that of CD9. Evidently, the levels of CD5L, CLEC3B, and SERFINF1 were significantly increased in cancer EVs (p < 0.01), as were those of ITIH4, SAA4, SERFINC1, and C20ORF3 (p < 0.05).