SFTPC and pulmonary fibrosis: A family history of pulmonary fibrosis can also be an expression of other gene mutations, such as surfactant-related genes, Nogee et al. reported the first recognised case of familial pulmonary fibrosis in 2001 [73], linked to a heterozygous mutation in surfactant protein C, with subsequent discovery of different mutations in the same gene and in other surfactant related genes, with substantial heterogeneity in clinical phenotypes.