BAX and hepatocellular carcinoma: Similarly, Kumar et al. [130] reported that poly(lactic- co-glycolic acid)-loaded NPs of BA (PLGA-loaded NPs of BA) significantly decreased the expression of i-NOS, Bcl-2, and Bcl-xl and increased the expression of BAD, BAX, and caspase-9/3 compared to the untreated control in a diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) rat model.