Kim et al. [44] revealed that Rh2 hyaluronic acid-functionalized zinc oxide (Rh2HAZnO) enhanced p53, pp38, Bax, PARP, and ROS production and reduced the expression of Bcl-2 compared to Rh2 alone in A549 lung cancer, HT29 colon cancer, and MCF7 breast cancer cells. This evidence concerns the gene BAX and breast carcinoma.