PCNA and malignant colon neoplasm: Similarly, Qiu et al. [162] reported that Rg3 co-loaded with poly(ethylene glycol)-block-poly(L-glutamic acid-co-L-phenylalanine) (mPEG-b-P(Glu-co-Phe)) NPs (Rg3-NPs) significantly reduced proliferating cell nuclear antigen (PCNA) and increased caspase-7/9/3 compared to Rg3 alone in a colon cancer xenograft mouse model.