Similarly, B-AgNPs and F-AgNPs derived from Bacillus tequilensis and Calocybe indica (milky mushroom) extract induced apoptosis via the activation of p53, p-Erk1/2, and caspase-3 signaling and the downregulation of Bcl-2 in MDA-MB-231 breast cancer cells [62]. Here, CASP3 is linked to breast cancer.