Vasconcelos et al. [172] demonstrated that poly(ε-caprolactone) lipid-core NPs containing lycopene-rich extract from red guava (nano-LEG) were more effective and safe in MCF-7 breast cancer cells compared to the LYC control via the inhibition of NF-kB activation and ROS production. This evidence concerns the gene NFKB1 and breast carcinoma.