Consistent with this, transgenic mice expressing increased levels of Akt or constitutively active Akt in the basal layer were more sensitive to two-stage skin carcinogenesis and to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate [33] and overexpression of Akt in keratinocytes accelerated tumorigenesis in vivo [31]. The gene discussed is AKT1; the disease is neoplasm.