It has been reported that S100A6 is found in both the nucleus and the cytoplasm in many mature epithelia and in all endothelial cells, stromal cells such as fibroblasts and myofibroblasts, and nerve sheath cells [31], and enriched at the nuclear envelope in A431 human epidermoid carcinoma cells [32], consistent with the nuclear localization of HMG20A. This evidence concerns the gene HMG20A and squamous cell carcinoma.