CSF3 and infection: Thus, careful preemptive measures and supportive care, like rhEPO and G-CSF for cytopenia, acyclovir, and trimethoprim-sulfamethoxazole prophylaxis, prompt evaluation of potential signs or symptoms of infection, as well as use of concomitant medications to reduce gastrointestinal adverse events (nausea, constipation), are considered crucial to improve patients’ tolerance and satisfaction to bendamustine treatment.