SAV1 and intrahepatic cholangiocarcinoma: In contrast, loss of Hippo kinase activities, as in mice with a genetic deletion of Nf2 [10,43], Mst1/2 [43,44], Lats1/2 [45,46], or Sav1 [47], causes hepatomegaly and liver cancers, including HCC, ICC, and/or the HCC/ICC mixed form.