In addition, Hu et al. [86] reported that miR-665 is highly expressed in HCC, suppresses LATS1 activity and enhances activated YAP by negatively regulating the tyrosine phosphatase receptor type B (PTPRB) gene, the protein of which phosphorylates the LATS1 Hippo kinase. The gene discussed is LATS1; the disease is hepatocellular carcinoma.