Infiltration of macrophages in the tumor microenvironment is considered an adverse event for tumor growth: macrophages secrete epidermal growth factor receptor (EGFR) family ligands which finally trigger the production of signal transducer and activator of transcription 3 (STAT3) and NF-kB, both of which contribute to tumor development and resistance to therapy [8]. The gene discussed is NFKB1; the disease is neoplasm.