Both methods showed concordant results, pointing out the involvement of functional pathways that show the cooperation of genes located on 1q and 16q, such as “NOTCH2 Activation and Transmission of Signal to the Nucleus,” “NOTCH3 Activation and Transmission of Signal to the Nucleus,” and “Formation of the beta-catenin:TCF transactivating complex.” Indeed, the involvement of Notch signaling system in breast cancer has been repeatedly suggested in the literature (for a review see Mollen et al. 2018 [73]). The gene discussed is HNF4A; the disease is breast carcinoma.