A second example is provided by the CBFB gene (Core-Binding Factor Subunit Beta), the beta subunit of a heterodimeric core-binding transcription factor that has been reported as frequently mutated in breast cancer [50]; it is located in chromosome 16q and shows a decreased expression in 16q-loss chromogroups (Figure 7B) and a high frequency of point mutations in group A and B1 (Figure S5). The gene discussed is CBFB; the disease is breast cancer.