TP53 and breast ductal adenocarcinoma: The higher frequency of TP53 mutations in ductal carcinomas and CDH1 mutations (mainly nonsense or splice-site mutations) in lobular carcinomas was found to be a general feature of those histotypes, as shown in the oncoplot of Figure S4, including 709 ductal and 149 lobular BRCA samples analyzed by WES in TCGA study.