The higher frequency of TP53 mutations in ductal carcinomas and CDH1 mutations (mainly nonsense or splice-site mutations) in lobular carcinomas was found to be a general feature of those histotypes, as shown in the oncoplot of Figure S4, including 709 ductal and 149 lobular BRCA samples analyzed by WES in TCGA study. Here, CDH1 is linked to breast ductal adenocarcinoma.