Collectively, these data indicated that transcriptional decrease of CDH1 is only a weak effect in invasive ductal carcinomas, suggesting that the frequent loss of 16q in such histological subtype might be explained by the cancer evolutionary advantage due to reduced transcription of other 16q genes [72] or by a higher sensitivity to CDH1 haploinsufficiency due to the cooperative effect of other gene mutations. The gene discussed is CDH1; the disease is cancer.