RAC1 and breast carcinoma: Finally, several functional interactions among the “core 1q-OverUpT” genes could be tracked to well-described molecular changes supporting cancer progression, such as SLC30A1 that encodes a zinc transporter [100], Trim46 that (together with 1q-located TRIM11 and TRIM17) belongs to a large gene family involved in breast cancer [101,102], and TUFT1 (Tuftelin) that promotes triple negative breast cancer metastasis and stemness by upregulating the Rac1/beta-catenin pathway [103].