Given that the largest number of lobular carcinomas was observed in group A (bearing both 1q-gain and 16q-loss), it is reasonable to hypothesize that cooperative functional networks of 1q and 16q genes could operate both in lobular and ductal carcinomas, the two histotypes being mainly differentiated by the deeper transcriptional downregulation of 16q-CDH1 in lobular carcinomas. The gene discussed is CDH1; the disease is breast ductal adenocarcinoma.