This observation was in agreement with previous immunohistochemistry studies showing that low-grade invasive ductal carcinomas have stronger E-cadherin membrane staining than that seen in the normal breast epithelial cells, while E-cadherin loss may occur as a late event in a subgroup of high-grade invasive ductal carcinomas [47,48]. The gene discussed is CDH1; the disease is invasive ductal breast carcinoma.