In support of the model shown in Figure 6, it is important to recall that the treatment of BC consists in the inhibition of E2:ERα signaling either by reducing the circulating plasma E2 levels (i.e., ovariectomy, chemical castration, aromatase inhibitors treatment) or by inhibiting the ERα transcriptional activity [3,94]. The gene discussed is CYP19A1; the disease is breast cancer.