As NFX1-123 is not targeted by 16E6 and E6AP for rapid ubiquitin-mediated degradation like NFX1-91, and because NFX1-123 has opposing effects to NFX1-91 in HPV associated cancers, more recent studies have focused on defining and understanding the role NFX1-123 plays in cancers caused by HR HPV. The gene discussed is UBE3A; the disease is cancer.