Immunohistochemistry (IHC) analysis of localized PCa tumors from 118 neoadjuvant-naïve patients who underwent radical prostatectomy showed great variability in the expression levels of inflammatory mediators among tumors [17]; however, the expression of IL-6, IL-1β, and nuclear factor (NF) kappa B (NF-κB), a known mediator of inflammatory responses, were detected in almost all samples (>94–95%). This evidence concerns the gene IL1B and posterior cortical atrophy.