In immunity, HIF-1 seems to be expressed in virtually all innate and adaptive immune cell populations including myeloid lineages including monocytes, macrophages and neutrophils [80,81], dendritic cells [82], T cells and B cells and NK cells and innate lymphoid cells (ILCs) (reviewed in [83,84,85]) while HIF-2 has been demonstrated in certain immune cells such as in tumor-associated macrophages, in vitro expanded CD8+ T cells and in response to cytokines and hypoxia (reviewed in [85,86]). The gene discussed is CD8A; the disease is neoplasm.