Single cell RNA sequencing of mouse tumor-infiltrating NK cells identified Hif1a to be upregulated in the hypoxic microenvironment of solid tumors while conditional deletion of Hif1a-/- in tumor-infiltrating NK cells activated the NFκB pathway, elevated expression of activation markers, effector molecule and increased INF-γ production in correlation with elevated oxygen consumption rate/extracellular acidification rate (OCR/ECAR) ratio finally reducing tumor growth [245]. This evidence concerns the gene HIF1A and neoplasm.