The TAGE-RAGE axis-mediated, NOX-induced production of ROS has been shown to promote crucial steps in tumor angiogenesis, namely, the proliferation of and tube formation by EC, which are crucial steps in tumor angiogenesis, through the expression of VEGF, which, in turn, was induced via the transcriptional activation of NF-κB and activator protein-1 [51,85,86]. Here, NFKB1 is linked to neoplasm.