Because both P-gp and CFTR are members of the ABC-transporters superfamily, the inhibitory effects of CBD on P-gp, as previously demonstrated [23] could also inhibit the CFTR activity and, in consequence, increase the risk of infection, resulting in inadequate microbial killing, as described in the cystic fibrosis disease [59,60]. The gene discussed is ABCG2; the disease is infection.