In the state of low-grade chronic inflammation, there is a greater number of pre-adipocytes that express FSLT1; however, morbidity and super obesity are associated with a decline in FSTL1 due to loss of adipogenesis, increased maturated adipocytes, cellular senescence, and anti-apoptotic reduction in FSLT1 [26]. The gene discussed is FSTL1; the disease is obesity due to melanocortin 4 receptor deficiency.