SFRP5 is associated with comorbidities such as obesity, DM2, insulin resistance, and atherosclerosis, inhibiting the wingless-type family member 5a signaling (Wnt5a) and the non-canonical Wnt family and regulating the expression of pro-inflammatory cytokines [14,21]. Here, WNT5A is linked to obesity due to melanocortin 4 receptor deficiency.