Although, the hypothesis regarding the relationship between the risk of myocardial infarction and COX-2 selectivity has not been confirmed, there are two NSAIDs: diclofenac (nonselective COX inhibitor) and rofecoxib (selective COX-2 inhibitor), which used long-term and in high doses, have been found to be associated with the increased risk of myocardial infarction [51]. This evidence concerns the gene PTGS2 and myocardial infarction.