Regarding the cardiac parameters, CHF individuals bearing the TT genotype demonstrated a significant reduction in EF (mean EF = 36 ± 14% (TT) vs. 43 ± 15% (CT) and 43 ± 15% (CC); p = 0.033) in contrast to other genotype carriers; moreover, they had a significantly higher concentration of NT-proBNP in the blood (median NT-proBNP concentration = 3953 pg/mL (TT) vs. 2697 pg/mL (CT) and 2077 pg/mL (CC); p = 0.018). The gene discussed is NPPB; the disease is congestive heart failure.