ApoA-I (OMIM: 107680) is a 243-amino acid apolipoprotein encoded by ApoA-I gene, located on the 11q23-q24 chromosome; to date, more than 60 mutations have been described, with the majority associated with hypoalphalipoproteinemia [86]. This evidence concerns the gene APOA1 and hypoalphalipoproteinemia.