Accordingly, RYGBP surgery and sleeve gastrectomy (SG) surgery were able to increase ABCA1-independent CEC in 37 obese patients with type 2 Diabetes Mellitus (T2DM) also 5 years after the procedure, while other clinical interventions as intensive medical therapy were unable to positively affect CEC [134]. Here, ABCA1 is linked to type 2 diabetes mellitus.