Again, Versmissen and colleagues compared male FH subjects with or CHD (n = 7 and 6, respectively) and their non-FH sibling: plasma from FH patients without CHD displayed a higher CEC compared to plasma from FH patients that experienced CHD, with respect to their non-FH sibling, and alteration in HDL composition, such as the levels of cholesterol, S1P and apoM [110]. The gene discussed is APOM; the disease is familial hyperaldosteronism.