APOA1 and type 2 diabetes mellitus: A typical feature of T2DM is the presence of Advanced glycation end (AGE) products, including AGE albumin: Machado-Lima and colleagues demonstrated that glycated albumin isolated from 14 patients with poorly controlled T2DM negatively impacts on cholesterol efflux to apoA-I, HDL2 and HDL3, mainly by downregulating ABCG1 expression and leading to a greater intracellular cholesterol accumulation [142].