SCARB1 and familial hyperaldosteronism: Similarly, Bellanger and colleagues showed that large HDL2 particles isolated from 12 FH patients receiving an aggressive cholesterol-lowering therapy, but still with a marked type IIa hypercholesterolemic phenotype, also display a reduced CEC both through ABCG1- and SR-BI-mediated pathways, inversely correlating with carotid IMT [109].