In addition, in COVID-19 convalescent subjects these HLA-A*02:01-restricted SARS-CoV-2-reactive CD8+ T cells expressed granzymes and/or perforin, but were negative for CD38, HLA-DR, PD-1, and CD71 activation markers, while all these markers where positive in acute phase patients [58]. Here, HLA-A is linked to COVID-19.