Supporting this hypothesis, a study performed on two unrelated families (each one with a pair of male brothers with severe COVID-19) identified two variants in TLR7: (I) a pLOF variant NM_016562.3 c.2129_2132del, p.(Gln710Argfs*18) in the first family and (II) a missense variant NM_016562.3 c.2383G>T, p.(Val795Phe) in the second family. Here, TLR7 is linked to COVID-19.