APOE and type 2 diabetes mellitus: Similarly, comparing COVID-19 patients who died with subjects from the UK biobank excluding COVID-19+ surviving subjects, the ApoE ε4ε4 homozygous genotype was found to be significantly associated with an increased risk of death vs. ε3ε3 homozygotes (Table 3) even after the exclusion of patients carrying e4 with dementia, hypertension, cardiovascular disease, and type 2 diabetes [123].