A notable effort was made to analyze 12 autosomal loci (STAT1 on chromosome 2, TLR 3 on chromosome 4, IRF7 and UNC93B1 on chromosome 11, TBK1 and STAT2 on chromosome 12, IRF9 and TRAF3 on chromosome 14, TICAM1/TRIF and IRF3 on chromosome 19, IFNAR1 and IFNAR2 on chromosome 21) and one X linked locus (NF-κB essential modulator—NEMO/IKBKG) in COVID-19 patients with life-threatening pneumonia vs. mild and asymptomatic COVID-19 cases (control group) [113,114]. This evidence concerns the gene IRF9 and COVID-19.