However, the alleles analyzed in this study HLA-A*02:01, HLA-B*08:01, HLA-A*01:01, HLA-B*18:01, HLA-C*07:01 are predicted to exhibit a good viral antigen presenting capacity, with HLA-A*02:01 offering the highest numbers of both tightly (dissociation constant < 50 nM, peptide number 267) and loosely (dissociation constant < 500 nM, peptide number 795) SARS-CoV-2 peptides [51,56], thus making the relationship between COVID-19 death rates and in silico estimated HLA antigen presenting capacity less clear. This evidence concerns the gene HLA-B and COVID-19.