Similarly, analyzing the HLA haplotype distribution in three Italian zones (northern, central and southern regions), the haplotype HLA-A*01:01g-B*08:01g-C*07:01g-DRB1*03:01g showed a positive correlation and the haplotype HLA-A*02:01g-B*18:01g-C*07:01g-DRB1*11:04g and a negative correlation with both COVID-19 incidence (number of cases/100,000 inhabitants) and mortality (number of deaths/100,000 inhabitants) at three out of four the analyzed timepoints (the first time point was reported to have no significant results because it was too premature) [56]. The gene discussed is HLA-DRB1; the disease is COVID-19.