Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) signaling pathways have emerged as important drivers of the development, growth, and metastasis of human malignancies including PCa, and accumulating evidence has illustrated that YAP/TAZ signaling is correlated with the metastasis of PCa [12,13]. The gene discussed is WWTR1; the disease is posterior cortical atrophy.