ALK and non-small cell lung carcinoma: Entrectinib is a TRKA, TRKB, TRKC, ROS1, and ALK multi-inhibitor, and data from three Phase I/II trials (ALKA-372-001, STARTRK-1, and STARTRK-2) reported an ORR for NSCLC patients of 70–75% with 10% of complete responses (CR), an mDOR of 12.9 months, and an mOS of 23.9 months (Table 4) [67,68,69].