The deregulated microRNAs were significant for pathways relevant to apoptosis, cell motility, proliferation, mitotic regulatory processes, phosphatidylinositol 3-kinase (PI3K) and Insulin–like growth factor-1 receptor (IGFR) transduction [91]; all those pathways grant for the tumor high metastatic capacity by inducing progression and invasion. This evidence concerns the gene PIK3CA and neoplasm.