SPP1 and glioblastoma: Our data strongly support that osteopontin and its receptor integrin αvβ3 engagement promotes glycolysis in GBM cells, evidenced by the fact that inhibition of integrin αvβ3 and osteopontin engagement, either by αvβ3 downregulation or using αvβ3 blocking antibody, decreases glucose uptake and increases mitochondrial function, as well as effectively reverses the metabolic shift toward glycolysis.