The first available data were focused on the mRNA expression of m6A writers (METTL3, METTL14, and WTAP), erasers (FTO and ALKBH5) and readers (YTHDF2) in peripheral blood mononuclear cells (PBMCs) from lupus affected patients [134]. This evidence concerns the gene ALKBH5 and systemic lupus erythematosus.