Adipokines, produced by AT, and secreted into the bloodstream during physiological conditions or in obesity, pathologically change the gene expression and secretory pattern of such compounds, significantly elevating the levels of proinflammatory molecules such as CCL2, IL-6, and resistin while decreasing the production of anti-inflammatory adiponectin and IL-10. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.