Despite the fact that serum proportion levels of K18 and ccK18 may be useful indicators of DILI, elevated levels of this protein are also found in patients with hypoxic hepatitis, alcohol steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), and other related disorders [263], in which may represent liver inflammation. Here, KRT18 is linked to metabolic dysfunction-associated steatohepatitis.