A phase I/II trial of pembrolizumab in pediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumor or lymphoma reported only five cases of severe neutropenia in 154 treated children (3.2%), whereas 13% of patients experienced severe infection (with one case of invasive Candida infection) and 1.3% encountered febrile neutropenia [168]. Here, CD274 is linked to infection.