ARMCX3 and hepatocellular carcinoma: To assess whether the protective effects of ARMCX3 invalidation on hepatic tumorigenesis in mice may occur in a cell-autonomous manner, we performed siRNA-mediated knockdown of ARMCX3 (80–90% of reduction of ARMCX3 expression) in two human HCC cell lines with high basal expression of ARMCX3: SNU423 and HepB3 (Figure 5A).