Ethaselen (1,2-(bis[1,2-benzisoselenazolone-3(2H)-ketone])ethane; BBSKE), a selenium-containing thioredoxin reductase inhibitor, was found to suppress irradiation-induced NF-kB activation when using A549 cells stably transfected with a NF-kB luciferase reporter [32]; it also showed a radiosensitizing effect in NSCLC cell lines and tumor models. Here, NFKB1 is linked to neoplasm.