Similar to their use in rodent models of AD, the accumulation of Aβ42 peptides and the aggregation of phosphorylated tau protein have been employed to generate zebrafish AD models either by direct Aβ42 peptide injections into the brain or by the overexpression of amyloid β42 or a phosphorylation-prone mutant form of tau protein to create stable transgenic zebrafish. This evidence concerns the gene MAPT and Alzheimer disease.