APOE and atherosclerosis: Using young and replicative human senescent ECs as well as different animal models of atherosclerosis (apoE−/−, Arg2+/+ and Arg2-deficient apoE−/−), an in-depth report published on autophagy demonstrated the role of Arginase-2 (ARG2) and the mechanisms potentially underlying the modulation of endothelial autophagy [149].