IRS2 and Hypertension: For instance, a KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis of differentially regulated genes in Marfan syndrome revealed other genes involved in the cGMP–PKG signaling pathways, including Irs2, Irs3, (which encode insulin receptor substrates) and Adcy7 (encoding adenylate cyclase 7) involved in the pathogenesis of hypertension [56].