Ceftolozane/tazobactam, ceftazidime/avibactam and meropenem/vaborbactam are novel antibiotics (beta-lactam/beta-lactamase inhibitor) approved for HAP and VAP, with good results for several Gram-negative bacilli that represent a major problem, especially in the critical care setting. Here, LACTB is linked to ventilator-associated pneumonia.