Well-fed AIP mice showed a significant overexpression of the insulin-dependent cyp7a1 gene compared to WT mice (2.7-fold induction), and fasting strongly induced its over-expression in both strains (6.4-fold induction in WT and 2.9-fold induction in AIP mice) (Figure 2g). The gene discussed is CYP7A1; the disease is autoimmune pancreatitis.