Based on these results, it is tempting to speculate that pAkt induces rapid Forkhead Box O1 (FOXO1) phosphorylation and breaks up the FOXO1/PGC1α complex, causing the sustained repression of alas1 transcription in the liver of AIP mice treated with Ins-ApoAI. This evidence concerns the gene APOA1 and autoimmune pancreatitis.