VWF and von Willebrand disease 1: vWD Vicenza is considered now as a dominant vWD type 1 qualitative defect with normal secretion but rapid clearance of vWF with equally low levels of FVIII:C, vWF:Ag, vWF:RCo, vWF:CB and the presence of unusually large vWF multimers in the plasma [65].