In agreement with previous reports [7,8,9], there are variants in CYP2C8, CYP2D6, CYP3A4, CYP3A5, SLCO2B1, ABCB1, ABCC2, CES1, and G6PD that could help to improve the clinical outcome of the COVID-19. This evidence concerns the gene CYP3A4 and COVID-19.