CCDC186 and breast carcinoma: To further investigate whether the increment of HA secretion and HAS2 expression by NHDF was specifically due to the c10orf118 secreted into the medium by breast cancer cells, CM of MCF-7 was incubated with 4 μg/mL of anti-c10orf118 antibody (HPA018019) and subsequently used for NHDF treatment (Figure 7A).