Although we cannot exclude the presence of small amount (undetectable by the antibody) of the processed form in the medium of both MCF-7 and MDA-MB-231 cells, our data point at a biological function for the full size c10orf118 protein, with the 50 kDa fragment that may be a degradation product, specifically produced by cell line(s) (i.e., 8701-BC). The gene discussed is CCDC186; the disease is breast cancer.